脐血干细胞治疗肌萎缩性(脊髓) 侧索硬化

时间 : 2009-12-03 03:39:06 来源：www.91sqs.com

[摘要]

A study at the University of South Florida has shown that transplants of mononuclear human umbilical cord blood (MNChUCB) cells may help patients suff

AstudyattheUniversityofSouthFloridahasshownthattransplantsofmononuclearhumanumbilicalcordblood（MNChUCB）cellsmayhelppatientssufferingfromAmyotrophicLateralSclerosis（ALS）,alsoknownasLouGehrig'sdisease.Adiseaseinwhichthemotorneuronsinthespinalcordandbraindegenerate,ALSleavesitsvictimswithprogressivemuscleweakness,paralysisand,finally,respiratoryfailurethreetofiveyearsafterdiagnosis.

Inthisstudy,USFresearcherstransplantedhumanumbilicalcordblood（HUCB）cellsintomousemodelswithALS.Cellsweretransplantedatthreedifferentdosestrengthlevels--low,moderateandhigh--todeterminethedegreetowhichdoselevelsoftransplantedcellsmightdelaydiseasesymptomprogressionandincreaselifespan.InresultsrecentlypublishedonlineatPloSOne（PublicLibraryofScience）,researchersdeterminedthatthemoderate-strengthdoseofHUCBcellswasmosteffectiveinincreasinglifespanandreducingdiseaseprogression.

"OurresultsdemonstratethattreatmentforALSwithanappropriatedoseofMNChUBCcellsmayprovideaneuroprotectiveeffectformotorneuronsthroughactiveinvolvementofthesecellsinmodulatingthehostimmuneinflammatorysystemresponse,"saidthestudy'sleadauthorSvitlanaGarbuzova-Davis,PhD,DSc,oftheCenterofExcellenceforAgingandBrainRepairatUSF.

Accordingtotheresearchteam,modulatingimmuneandinflammatoryeffectorswithHUCBcellscouldhaveaprotectiveeffectondyingmotorneurons.TheteamhadpreviouslyshownthathUBCcelltransplantsreducedinflammationandprovidedneuroprotectioninmodelsofstrokeandAlzheimer'sdisease.

"ThispreclinicalstudyindicatesthatMNChUBCcellsmayprotectmotorneuronsbyinhibitinganimmuneinflammatoryresponsebydecreasingpro-inflammatorycytokines,signalingproteinsinthebrainandspinalcordthatplayaroleinimmuneresponse,"Garbuzova-Davisandcolleagueswrote."Proinflammatorycytokinesmaybeindirectmediatorsforglialcells'contributiontomotoneurondeathandthedecreaseinthesecytokinesmightbeduetoareductionofactivatedmicroglia,thecellsthatformactiveimmunedefenseinthecentralnervoussystem."

Theresearchteamnoted,however,thatthemechanismunderlyingthebeneficialeffectofhUBCcellsforrepairingdiseasedmotorneuronsinALSstillneedsmoreclarification.

Suggestingthat'moreisnotbetter,'itwasthemoderate,notthehigh,doseofhUBCcellsthatprovedmosteffective.Researchersspeculatedthatthehighdosemayhavebeenlesseffectivebecauseitinducedanimmunologicalconflictwithinthemousemodel.

"Futurestudiesshouldlookatmultipleinjectionsofsmallerdosesovertime,inordertohelptranslatethisresearchtoclinicaltrials,"accordingtoco-authorPaulR.Sanberg,PhD,DSc,directoroftheCenter.

"DevelopinganeffectivetreatmentforALSiscomplicatedbythediffusenatureofmotorneurondeath,"concludedGarbuzova-Davis."However,celltherapymayofferapromisingnewtreatment."

Theotherco-authorsofthestudywereCyndyDavisSanbergandNicoleKuzmin-NicholsofSaneronCCELLTherapeutics,Inc.,andAlisonE.Willing,CarmelinaGemma,PaulaC.Bickford,ChristinaMiller,andRobertRossifromUSF.

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