RestrictionofDietaryCalories，FatandIronImprovesNon-alcoholicFattyLiverDiseaseMikaYamamotoDepartmentofGastroenterologyandHepatology，DivisionofClinicalMedicineandBiomedicalSciences，InstituteofMedicalScience，MieUniversityGraduateSchoolofMedicineAbstractBackground:Thepathogenesisofnon-alcoholicsteatohepatitis（NASH）isunclear.RecentstudiessuggestedthatoxidativestressplaysanimportantroleinthemechanismofNASH.Excessiveaccumulationofironinthelivercausesoxidativestress.Theaimofthepresentstudywastoevaluatethegradeofhepaticironaccumulationandthetherapeuticresponsetorestrictionofcalories，fatandironinpatientswithnon-alcoholicfattyliverdisease（NAFLD）.
Methods:Twenty-sevenNAFLDpatientswereenrolled.Thepatientswerecategorizedintotwogroups:17patientswithNASHand10withsimplesteatosis.TwelveNAFLDpatients（NASH，n=9;simplesteatosis，n=3）weregivenadietaryprescriptionincludingrestrictionofenergy，fatandiron.
Results:Positiveironstainingwasobservedin71%and50%ofpatientswithNASHandsimplesteatosis，respectively.Theaverageenergyintake，fatenergyfractionandironintakedecreasedsignificantly6monthsafterthebeginningofthedietinallpatients.Inaddition，thelevelsofserumtransaminaseandferritinweresignificantlydecreased.
Conclusion:Dietaryrestrictionofcalories，fatandironimprovedNAFLD.Reducedserumferritinlevelsappeartoreduceoxidativestressintheliver.上一篇：HBV与增加
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