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关于肠阿米巴病的研究进展

时间 : 2009-11-30 13:35:14 来源:www.yxsjy.net

[摘要]

关键词:肠阿米巴病溶组织内阿米巴同工酶编码基因

  肠阿米巴病是由溶组织内阿米巴(Entamoebahistolytica)引起的肠道传染病

  一

  Sargeaunt[1]分析比较了来自世界各地的6000多个溶组织内阿米巴分离株的同工酶谱

  二

  致病性溶组织内阿米巴滋养体膜上有特异性的30000

  三

  Clark等[9]证明了两群溶组织内阿米巴的核蛋白体基因(rDNA)

  上述这些利用两群溶组织内阿米巴的酶

  1.诊断:(1)从新鲜粪便中查到吞噬有红细胞的滋养体或从活检组织中查到滋养体是确诊肠阿米巴病最可靠的依据。(2)从粪便标本中仅查到

  2.治疗:肠阿米巴病一经诊断,即患者确实被溶组织内阿米巴感染,

  3.流行病

  作者单位:100050北京热带医

  1 SargeauntPG.ThereliabilityofEntamoebahistolyticazymodemesinclinicaldiagnosis.parasitologyToday,1987,3:40-43.

  2 GathiramV,JacksonTF.FrequencydistributionofEntamoebahistolyticazymodemesinaruralSouthAfricanpopulation.Lancet,1985,1:719-721.

  3 MirelmanD.EffectofcultureconditionsandbacterialassociatesonthezymodemesofEntamoebahistolytica.ParasitologyToday,1987,3:37-40.

  4 SargeauntPG,BavejaUK,NandaR,etal.InfluenceofgeographicalfactorsinthedistributionofpathogeniczymodemesofEntamoebahistolytica:identificationofzymodemesⅪⅤinIndia.TransRSocTropMedHyg,1984,78:96-101.

  5 BlakelyP,SargeauntPG,ReedSL.Aimmunogenic30-kDasurfaceantigenofpathogenicclinicalisolatesofEntamoebahistolytica.JInfectDis,1990,162:949-954.

  6 QueX,ReedSL.TheroleofextracellulercysteineproteinasesinpathogenesisofEntamoebahistolyticainvasion.ParasitologyToday,1997,13:190-194.

  7 PetriWAJr,JacksonTF,GathiramV,etal.PathogenicandnonpathogenicstrainsofEntamoebahistolyticacanbedifferentiatedbymonoclonalantibodiestothegalactose-specificadherencelectin.InfectImmun,1990,58:1802-1806.

  8 LeippeM,BahrE,TannichE,etal.Comparisonofpore-formingpeptidesfrompathogenicandnonpathogenicEntamoebahistolytica.MolBiolParasitol,1993,59:101-110.

  9 ClarkCG,DiamondLS.RibosomalRNAgenesof“pathogenic”and“nonpathogenic”Entamoebahistolyticaaredistinct.MolBiolParasitol,1991,49:297-302.

  10 TachibanaH,IharaS,KobayashiS,etal.DifferencesingenomicDNAsequencebetweenpathogenicandnonpathogenicisolatesofEntamoebahistolyticaidentifiedbypolymerasechinreaction.JClinMicrobiol,1991,29:2234-2239.

  11 EdmanU,MerazMA,RausserS,etal.Characterizationofanimmuno-dominantvariablesurfaceantigenfrompathogenicandnonpathogenicEntamoebahistolytica.jExpMed,1990,172:879-888.

  12 DiamondLS,ClarkCG.AredescriptionofEntamoebahistolyticaschaudinn,1903(EmendedWalker,1911)separatingitfromEntamoebadisparbrumpt,1925.JEukaryotMicrobiol,1993,40:340-344.

  13 WHO.Amoebiasis.WklyEpidemiolRec,1997,72:97-99.

  14 HaqueR,NevilleLM,HahnP,etal.RapiddiagnosisofEntamoebainfectionbyusingEntamoebaandEntamoebahistolyticastoolantigendetectionkits.JClinMicrobiol,1995,33:2558-2561.

  15 WalderichB,BurechardGD,KnoblochJ,etal.DevelopmentofmonoclonalantibodiesspecificallyrecognizingthecyststageofEntamoebahistolytica.AmjTropMedHyg,1998,59:347-351.

  16 HaqueR,FaruqueAS,HahnP,etal.EntamoebahistolyticaandEntamoebadisparinfectioninchildreninBangladesh.JInfectDis,1997,175:734-736.

  17 TachibanaH,TakekoshiM,ChengXJ,etal.BacterialexpressionofaneutralizingmousemonoclonalantibodyFabfragmenttoa150-kilodaltonsurfaceantigenofEntamoebahistolytica.AmJTropMedHyg,1999,60:35-40.


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